The EHDS2 Regulation marks a milestone in the secure reuse of health data within the EU, with trust and privacy at its core. This paper highlights the importance of a centralized de-identification function under the supervision of National Health Data Access Bodies (HDABs). Such an approach promotes consistency, transparency, and interoperability, while preventing fragmentation and the risk of re-identification. It is a strategic investment in the legitimacy and scalability of European health data policy.