White Paper
Antibody-Drug Conjugates in Cancer Therapy
IQVIA Ark Patent Intelligence
Sep 16, 2025

Cancer remains one of the most formidable health challenges, affecting millions of lives across every corner of the globe. The World Health Organisation's 2024 report recorded 20 million new cancer cases and 9.7 million deaths in 2022, with projections reaching 35 million cases by 2050.2 Conventional cancer treatment options were quite systemic and non-specific, leading to side effects. Over decades, a remarkable shift towards more targeted and personalized therapies have led to the use of antibody-drug conjugates (ADCs) as a promising therapy for cancer.

ADCs are advanced therapies that link monoclonal antibodies (mAbs) to potent cytotoxic drugs, known as payloads, via cleavable or non-cleavable linkers. They deliver drugs directly to cancer cells by recognizing specific antigens, thereby minimizing harm to healthy tissue, and enabling a bystander effect that kills nearby tumour cells. Despite their promise, ADCs are complex and costly to develop, with challenges, including off-target toxicity and drug resistance. Currently, 15 ADCs are approved for various cancers, such as breast, blood, gastric, urothelial, cervical, and lung cancers, and around 200 are in clinical trials, including 24 in Phase III, all driven by advances in antibody, linker, and payload technologies.

Today, ADCs have proven to be game changers in cancer therapy with growing market needs. The first ADC drug approval, Pfizer's MylotargTM (Gemtuzumab ozogamicin) by the US Food and Drug Administration (FDA) in 2000 for treating acute myeloid leukaemia (AML), marked a milestone in precision oncology. The European Medicines Agency (EMA) followed with approval in 2018, granting it orphan drug status due to the rarity of AML. The USA ADC market, valued at USD 11.3 billion in 2023, is projected to grow rapidly in the upcoming years.

Ark Patent Intelligence offers comprehensive insights into the global ADC drug market. It provides extensive worldwide information on drug approvals, market insights, key patents, regulatory protections, litigation trends, and detailed in-depth analyses of marketed, registered and phase III drugs covering more than 30 ADCs.

Explore how ADCs are transforming cancer therapy and reshaping market dynamics. Read this white paper for insights on patent strategy, biosimilar timelines, and innovation opportunities in oncology.

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