Loss of Protection (LoP) is a pivotal moment in the drug lifecycle. Once generics and biosimilars enter the market, competition intensifies, pricing adjusts quickly and brand performance begins to erode. With more than 500 molecules expected to lose protection by 2034, the scale of upcoming LOP events is set to reshape market trajectories globally.

This article highlights the emerging post-LoP dynamics and shows how IQVIA’s enhanced LoP curve modelling delivers the insights needed to navigate them.

What You’ll Learn

The forces driving a new wave of post-LoP change

A high-level look at what’s accelerating erosion pressure — from cost containment measures to growing demand for affordable therapies — and how these trends shape brand performance.

How erosion differs across global markets

A concise overview of the regional differences that influence post-LoP dynamics, including uptake behavior, pricing responses and policy environments.

How advanced modelling clarifies post LOP performance

An introduction to IQVIA’s data-driven approach to forecasting brand decline and generic uptake, with detailed curve structures and benchmarks available in the full article.

How enhanced LOP curves support stronger decision making

How expanded data coverage and improved modelling support stronger forecasting, pricing, market access and lifecycle decisions.

Download the full article for deeper insight into post LOP dynamics, regional variations and the modelling approach that supports more confident forecasting, pricing and competitive planning.

More about IQVIA Forecast Link: As part of the IQVIA Analytics Link Ecosystem, Forecast Link provides ten‑year sales value, volume, patient‑day and implied price forecasts for 10,000 drugs across 600 diseases and 80+ countries. Updated quarterly and powered by transparent, systematic algorithms plus analyst insight, it generates baseline trajectories and “events” them for predicted new launches and loss‑of‑protection using a clear share‑shift approach. Explore the full capability on our website or contact IQVIA to request a demonstration.

Accelerate your forward-looking analysis with agentic AI–driven insights (or directly in the module)

Forecast Link is now integrated into IQVIA Global Market Insights (GMI) Agent together with other IQVIA gold standard datasets. Leveraging advanced AI capabilities, GMI Agent provides an instant, unified view of the global market landscape including forward-looking insights with pipeline analysis, loss-of-protection timelines, and brand-level market forecasts, so you can anticipate change and act with confidence. Visit our website to learn more.