Article
Therapeutic Breakthroughs Drive Dealmaking in Endocrine and Metabolic Disorders
IQVIA Pharma Deals
Dec 18, 2023
Endocrine and metabolic diseases have increasingly become more prominent in dealmaking within the life sciences sector, as high prevalence of the diseases combined with the significant unmet medical need has piqued the interest of innovators.Notably, there has been a marked increase in endocrine/metabolic deal volume from 2022 to 2023, with drug candidates targeting obesity, diabetes and rare metabolic disorders being the key drivers of several high-profile deals, particularly in relation to novel therapeutic modalities and delivery approaches.

Despite significant advances within the field in recent years, there continues to be an unmet medical need for patients living with endocrine and metabolic disorders. This article will discuss life science deals that have been primarily driven by endocrine, metabolic and nutritional disease indications as defined by WHO ICD-10 code and sourced from the IQVIA Pharma Deals platform. Endocrine and etabolic deals have seen an uptick in recent years and now represent 8% of all publicly disclosed deals in Pharma Deals, compared to oncology which is the leading dealmaking therapeutic area and comprises over 20% of all deals. So far in 2023, biopharma companies have committed up to $12.3 billion in M&A deals and up to $12.5 billion in potential aggregate total deal value on alliances focused on endocrine/metabolic assets, as they look to invest in the growing market. 

Technological advances have unveiled new drug targets and mechanisms of action which have led to several endocrine/metabolic assets successfully reaching the clinic as well as a number of notable regulatory breakthroughs for the field. For example, glucagon-like peptide-1 (GLP-1) receptor agonists have drawn significant attention in recent months due to their transformative potential to treat both diabetes and obesity. 

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