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The molecular diagnostics (MDx) landscape continues to evolve rapidly, shaped by the aftershocks of the COVID-19 pandemic and a renewed focus on broader infectious disease testing. At IQVIA MedTech, we recently presented our latest findings at AMP 2025 Analyst Day, highlighting the shifts, challenges, and opportunities shaping the molecular market today—and what lies ahead.
Beyond COVID: A Return to Growth
While COVID-19 revenues declined significantly in 2024, the broader molecular market proved its resilience, posting high single-digit growth when excluding COVID-related testing. This rebound has pushed market performance above pre-pandemic levels, signalling strong recovery and renewed investment across key diagnostic segments.
The Rise of the "Quademic"
In the U.S., what began as a "tripledemic"—with simultaneous surges in influenza, RSV, and COVID—has now evolved into a "quademic" with the resurgence of Norovirus. Despite being a gastrointestinal bug, its inclusion is due to being a winter pathogen that affects many of the same patients. Perhaps most notably, flu-related deaths surpassed those from COVID for the first time since the pandemic, marking the highest rates in 15 years. These epidemiological shifts are driving renewed demand for multiplex respiratory panels and stressing the importance of pandemic preparedness infrastructure.
These shifts are not just a coincidence—it’s a consequence of immunity debt.
During the height of the pandemic, reduced exposure to common respiratory and gastrointestinal pathogens (due to masking, lockdowns, and social distancing) led to a population-wide decline in baseline immunity. Now, as normal interactions resume, individuals—especially children and the elderly—are experiencing more intense and frequent infections from viruses they previously encountered with less severity.
A Changing Competitive Landscape
While COVID revenue declines affected top-line performance, all major industry players demonstrated healthy ex-COVID growth ranging from +3% to +20%. This broad-based recovery reflects strategic realignments, portfolio expansions, and new platform introductions—especially in STI, respiratory, and AMR-related testing.
Key Trends Shaping the Market
What’s Next in Molecular Diagnostics
As we look ahead, three forces are set to shape the future of molecular diagnostics:
The molecular diagnostics sector has shown not just resilience, but a remarkable capacity for reinvention. As we navigate a post-pandemic era marked by new clinical priorities and shifting epidemiology, one thing is clear: molecular testing will continue to be a cornerstone of modern healthcare—and IQVIA MedTech is here to guide the way forward.
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Forging a path for MedTech Innovation.
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