The GRACE Checklist: A Validated Assessment Tool for High Quality Observational Studies of Comparative Effectiveness

October 20, 2016
Nancy Dreyer
Nancy Dreyer, MPH, PhD
 AMCP published article by Nancy A Dreyer, PhD, MPH; Allison Bryant, MPH; and Priscilla Velentgas, PhD



BACKGROUND: Recognizing the growing need for robust evidence about treatment effectiveness in real-world populations, the Good Research for Comparative Effectiveness (GRACE) guidelines have been developed for noninterventional studies of comparative effectiveness to determine which studies are sufficiently rigorous to be reliable enough for use in health technology assessments.

OBJECTIVE: To evaluate which aspects of the GRACE Checklist contribute most strongly to recognition of quality.

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