For sponsors and CROs, the question is, "Exactly how do we effectively secure patient insights and weave them into trial design to better tackle the challenges of recruitment and engagement?" The truth is that there is no one-size-fits-all approach. Rethinking the trial experience through the eyes of the patient and their needs must be addressed from multiple angles and solutions. In this insight brief, we discuss five noteworthy ways sponsors, CROs and study teams are improving trial participation and engagement by using patients as partners.